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Glucophage

Manufacturer : Bristol-Myers Squibb (Merck)
Drug Class: Oral Antidiabetic Agents


Generic name: Metformin hydrochloride

Indications : NIDDM : monotherapy or in combination w/ other oral antidiabetics. NIDDM & IDDM : in combination w/ insulin.
Dosage :

ADULTS :

The usual starting dose is one 500-milligram tablet twice a day, taken with morning and evening meals. Your doctor may increase your daily dose by 500 milligrams at weekly intervals, based on your response up to a total of 2,000 milligrams.

An alternative starting dose is one 850-milligram tablet a day, taken with the morning meal. Your doctor may increase this by 850 milligrams at 14-day intervals, to a maximum of 2,550 milligrams a day.

The usual maintenance dose ranges from 1,500 to 2,550 milligrams daily. If you take more than 2,000 milligrams a day, your doctor may recommend that the medication be divided into three doses, taken with each meal.

CHILDREN :

For children 10 to 16 years old, the usual starting dose is one 500-milligram tablet twice a day with meals. The dosage may be increased by 500 milligrams at weekly intervals up to a maximum of 2,000 milligrams daily. Glucophage has not been tested in children younger than 10.

OLDER ADULTS :

Older people and those who are malnourished or in a weakened state are generally given lower doses of Glucophage because their kidneys may be weaker, making side effects more likely.

Contraindications : Diabetic coma; ketoacidosis; renal impairment; chronic liver disease; cardiac failure & recent MI; alcoholism; hypoxemia; shock. Pregnancy.

Special Precautions : Lactic acidosis is rare & may occur in significant renal failure. Regular renal monitoring is needed. Suspend therapy during surgery & clinical investigations using IV iodinated contrast media.

Adverse Reactions : GI disturbances, metallic taste. Rarely, lactic acidosis, mild erythema.

Drug Interactions : May cause hypoglycemia w/ sulfonylureas, insulin, -blockers or ACE inhibitors. Alcohol & IV iodinated contrast media may cause lactic acidosis. Glucocorticoids & diuretics.

How Supplied :

Glucophage: Tab 500 mg (film-coated) x 100's.
Glucophage 850: Tab 850 mg (film-coated) x 100's.

Glucophage full information


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